Abstract 3632: Analysis of supportive care medication use in metastatic colorectal cancer across racial and ethnic groups using SEER-Medicare

Abstract Background: This study investigates disparities in the use of adjunctive supportive care medications (SCM) among metastatic colorectal cancer (CRC) patients across different racial and ethnic groups. SCMs are central to symptom management and improving health-related quality of life in cancer treatment. Our goal was to identify potential disparities in medication use for neurological symptoms that may impact quality of life and symptom management in end-of-life care for metastatic colorectal cancer patients. Methods: Data were acquired from Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database covering 2005-2017. We included patients diagnosed with metastatic CRC who died between 2005-2017 with more than one year of Medicare enrollment. Logistic regression models evaluated the relationship between SCM use and race while adjusting for various covariates, including sex, race, age, marital status, education, income, residence, and Charlson Comorbidity Index. Non-Hispanic White (NHW) CRC patients served as the reference group for all comparisons. Results are reported as the adjusted Odds Ratio and 95% Confidence Interval. Results: After applying the inclusion/exclusion criteria, 28, 212 patients were included in the final analysis (NHW:72.81%, Black 12.67%, Hispanic 9.51%, Asian/Pacific Islander 4.65%). Racial and ethnic disparities in the use of multiple SCM drug classes were identified. The results are summarized in Table 1 Conclusion: Black CRC patients had significantly lower use of multiple SCM drug classes than NHW patients. Hispanic and Asian CRC patients' results were more heterogeneous, demonstrating both increased and decreased use for various SCM drug classes than NHW patients. These findings suggest varying patterns in medication use across racial and ethnic groups and require further investigation to understand further the causes and potential consequences of these differences in use Citation Format: Olga Trejos Kweyete, Yi Guo, Sherise Rogers, Lisa Scarton, David Deremer, Diana Wilkie, John Allen. Analysis of supportive care medication use in metastatic colorectal cancer across racial and ethnic groups using SEER-Medicare [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 3632.