HISTOPATHOLOGICAL STUDY OF LIVER ORGAN IN RATS RATS WHICH TREATED WITH ANTICANCER DRUG CYCLOPHOSPHAMIDE

Cyclophosphamide is a synthetic alkylating substance that resembles nitrogen mustard and is frequently used to treat cancer.Additionally, it is used to treat kidney illnesses (such as focal segmental glomerulosclerosis, steroid-resistant nephrotic syndrome, and lupus nephritis) and systemic vasculitides.Fifteen male rat was used in this study of it given Cyclophosphamide in two concentration 25 and 50 mg /day/ kg five for each group and it compared with control group which given distal water al groups treated for 28 day and all group was killed and liver tissue saved in formalin for tissue preparations Histopathological study appeared liver vascular congestion and necrosis in group which treated with group treated with 50mg/kg/day and sever congestion in group treated with 25 mg/ kg compared with normal liver tissue in control group.