SYNTHESIS¸ MOLECULAR DOCKING MODELING AND BIOLOGICAL EVALUATION STUDY FOR SOME AMID DERIVATIVE DEIVE FROME SOME ANTI-INFLAMMATORY DURGS

A series of amide derivatives were studied by reacting some drugs containing a carboxyl group (baclofen, indomethacin, etodolac, flurbiprofen) with an aniline derivative.4dimethylaminopyridine (DMAP) was then added, and the solution was cooled to a temperature of 0C with continuous stirring, followed by the addition of dicyclohexylcarbodiimide (DCC).The reaction was monitored using TLC.All new amide derivatives (1-4) were characterized by FT-IR, 1H-NMR, 13C-NMR, and some physical properties were also measured, such as color, Rf, and melting point.The biological effectiveness of the study was tested against a type of bacteria, one positive (Staphylococcus aureus), and one type of fungus (Candida albicans).The bacterial inhibitory biological activity of the compounds (1-4) was determined, and it was found that the derivatives possess very good efficacy at a certain concentration.The biological activity as antioxidants was also evaluated using the (Phosphomolybdate assay) method, and it was found that the derivatives have very good efficacy compared to ascorbic acid at a certain concentration, with compound 2 showing the highest antioxidant activity.The molecular interaction of the new amide derivatives with the protein 2X08 was also studied.