Role of 11β-hydroxysteroid dehydrogenase gene polymorphisms rs846910 and rs12086634 in the etiology of hepatocellular carcinoma

In Asia, the most frequent cause of hepatocellular carcinoma (HCC) is chronic hepatitis B. The hepatitis B virus's (HBV) genomic integration is probably a precursor to carcinogenesis. The integrated HBV genome may directly activate nearby cellular genes to give the liver cells a selective growth advantage. Our study's goal was to determine if genetic variants in 11β-HSD1, rs846910 and rs12086634 could be linked to chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). 150 samples were collected from people suffering from hepatitis B with HCC, HCC, and healthy people. The samples were genotyped for 11β HSD1 (rs846910 and rs12086634) using allele-specific real-time PCR. After performing genotyping of the 11β-HSD1 gene using real-time PCR, both alleles G and A of rs846910 were found to be more prevalent in the two groups of hepatocellular carcinoma and hepatitis B. This gives a clear indication about the possibility of contracting hepatocellular carcinoma and hepatitis B. A different result was found than previously, as the TT genotype of rs12086634 showed a protective effect against hepatocellular carcinoma and hepatitis B virus infection, while the AG genotype of rs846910 increased the risk of hepatocellular carcinoma. These genetic variations are clearly significant biomarkers for hepatocellular carcinoma.