Serum sirtuin 3 levels and multimodal abnormalities in brain structure and function in Parkinson’s disease patients with depression
Depression in PD patients is associated with lower serum SIRT3 levels, right amygdala atrophy, decreased spontaneous activity in MidFG.L and SPL.L, and altered FC in the DMN and SN.
Authors
- Xiaoxue Shi
- Yingyun Wang (ORCID: https://orcid.org/0009-0006-6917-0245)
- Haoran Peng (ORCID: https://orcid.org/0000-0002-7862-1013)
- Jinhua Zheng
- Yunfei Sun (ORCID: https://orcid.org/0009-0005-5564-6305)
- Qi Gu (ORCID: https://orcid.org/0000-0001-9387-9525)
- Jianjun Ma (ORCID: https://orcid.org/0000-0001-5825-1927)
- Siyuan Chen (ORCID: https://orcid.org/0000-0001-6146-5627)
- Qing Xu (ORCID: https://orcid.org/0000-0002-9804-3222)
- Xue Li (ORCID: https://orcid.org/0000-0002-0992-052X)
- Zonghan She
- Xuelin Qi
- Mengyan Zhang
Institutions
- Henan University (CN)
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Neurological Sciences
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1007/s10072-025-08170-2
- Citations
- 6
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- Health Commission of Henan Province
- Henan Provincial Science and Technology Research Project