Abstract 1302: A practical method of delivering induced electric field (iEF) therapy

Abstract Among non-pharmacological treatments, induced electric field (iEF) therapy is the only bioelectric approach that is truly contact-free and non-invasive. In iEF treatment, the permeability of magnetic fields varying in time is exploited to induce electric fields inside cells and tissues without the need for electrodes or adhesive contact with the skin. Induced electric fields are a non-ionizing form of electromagnetic radiation demonstrated to have strong anti-metastasis and anti-tumor activity in vitro and in vivo against triple negative breast cancer (TNBC), including significant host immune response in a pre-clinical animal model. Moreover, combination treatment of MDA-MB-231 and MDA-MB-468 cells with standard of care chemotherapeutic agents (paclitaxel, capecitabine) plus iEF in vitro, significantly improve their anti-viability and anti-proliferation activity (half-maximal inhibitory concentrations or IC50 values decreased by ∼50% for both paclitaxel+iEF and capecitabine+iEF treatments). EMBioSys has developed technology translating iEF therapy into clinical treatment and delivered in the form of wearable, washable garments such as camisoles. Special conducting threads integrated into the camisole enable a current to be driven through the insulated threads at voltages less than 10 Volts. The time-varying current generates a temporally varying magnetic induction within the space enclosed by the camisole and generates iEFs by Faraday’s law. We measured the magnetic inductions, compared with their calculated values, and determined iEF distributions within the space enclosed by the garment. We find that iEF intensities found to have anti-metastasis and anti-tumor effects in animal models of TNBC can be easily attained at human anatomical scales and delivered in a practical manner for use by patients. Our work lays the foundation for first in human studies by extending a treatment developed in the laboratory into a wearable and washable treatment device for cancer patients. Citation Format: Joseph West, Christopher Barron, Vish Subramaniam. A practical method of delivering induced electric field (iEF) therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1302.