Unravelling NK cell subset dynamics and specific gene signatures post-ibrutinib therapy in chronic lymphocytic leukaemia via single-cell transcriptomics
The CLL_NK subset plays a crucial role in the development and progression of CLL. The CNI, derived from its key genes, holds promise as a predictor of immune therapeutic responses, highlighting the significance of CLL_NK subset dynamics and their genetic underpinnings in CLL management.
Authors
- Chunlan Liu (ORCID: https://orcid.org/0000-0001-7281-0123)
- Tianjian Ding
- Sili Wang (ORCID: https://orcid.org/0000-0002-3672-1243)
- Aili Zhang (ORCID: https://orcid.org/0000-0001-7953-327X)
- Rong Zou
- Zhengzhuo Zhi
Institutions
- Longyan University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- 174th hospital of the People's Liberation Army (CN)
- Zhongshan Hospital of Xiamen University (CN)
- First Hospital of China Medical University (CN)
- Xiamen Chang Gung Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s12885-025-14166-0
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province