Abstract 5162: Decreases in blood pressure in a patient-derived xenograft model of pancreatic ductal adenocarcinoma

Abstract Introduction: Chemotherapy and radiation treatment cause cardiac injury and dysfunction. It remains unclear how cancer affects cardiac structure and function in therapy-naïve mice. Emerging data shows that epithelial ovarian cancer affects hemodynamics by causing cardiac atrophy, intrinsic cardiac dysfunction and arterial hypotension in mice. As pancreatic cancer is associated with heart disease risk, we wanted to explore if impaired hemodynamics occurs in other types of cancer. Methods: We utilized a patient-derived xenograft (PDX) model of pancreatic ductal adenocarcinoma (PDAC), established by implanting fresh tumor fragments from a human PDAC patient into NSG mice. Cardiovascular hemodynamic parameters were analyzed at 28-weeks post-tumor implantation, which coincided with an advanced stage of tumor development. Results: Invasive hemodynamic assessments showed a decrease in systolic and diastolic blood pressure. Conclusion: Independent of chemotherapy, pancreatic cancer causes arterial hypotension, impairing perfusion and overall recovery. Monitoring cardiovascular health is crucial to prevent further deterioration, optimize outcomes, and improve the quality of life for pancreatic cancer patients throughout their journey. Citation Format: Amelia R. Malicki, Leslie M. Ogilvie, Alexa N. King, Patrick Sanosa, Jana Michaud, Bridget Coyle-Asbil, Praveen Bhoopathi, Vignesh Vudatha, Jose G. Trevino, Keith R. Brunt, Jeremy A. Simpson. Decreases in blood pressure in a patient-derived xenograft model of pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 5162.