The Coast’s Natural Resources Offer a Promising in Silico Approach for Alzheimer’s Disease Medication

Abstract Alzheimer’s disease (AD) is becoming a significant health issue on an ecumenical scale, with a substantial financial and health impact on families and societies. It is characterized mostly by complete dementia, which includes memory loss, cognitive impairment, executive dysfunction, pearsonality alteration, and behavior changes. Furthermore, the majority of patients experience symptoms of mental disturbance. There are presently no treatments that can prevent or cure AD; however, medicine can provide temporary respite for these symptoms. Several studies have shown a correlation between the development of AD, disturbances in lipid metabolism, and neuroinflammation. We used an in silico strategy to investigate the bioactive flavonoids in the coastal prickly pear cactus cladode. This cactus cladode has four active compounds that bind well to and interact with the inhibitor sites of cyclooxygenase-2 (COX-2), soluble epoxide hydrolase (sEH), and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS1). The study suggests coastal prickly pear cactus cladode, which contains four bioactive flavonoids, may hold promise as a potential natural AD medication.