Non-TNFi biologic and targeted synthetic DMARDs in rheumatoid arthritis-associated interstitial lung disease: A propensity score-matched, active-comparator, new-user study

We did not find significant differences in mortality or respiratory hospitalization between RA-ILD patients initiating different non-TNFi b/tsDMARDs, though estimates were imprecise, and residual confounding may be present. These findings emphasize the need for clinical trials of advanced immunomodulatory therapies in RA-ILD.

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Publication Details

Journal
Seminars in Arthritis and Rheumatism
Published
2025-04-21
DOI
https://doi.org/10.1016/j.semarthrit.2025.152735
Citations
7
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
10.63
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article

Non-TNFi biologic and targeted synthetic DMARDs in rheumatoid arthritis-associated interstitial lung disease: A propensity score-matched, active-comparator, new-user study

Jeffrey R. Curtis, Christopher Wichman, Punyasha Roul, Scott M. Matson et al.
7 citations
Seminars in Arthritis and Rheumatism
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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article

Non-TNFi biologic and targeted synthetic DMARDs in rheumatoid arthritis-associated interstitial lung disease: A propensity score-matched, active-comparator, new-user study

Jeffrey R. Curtis, Christopher Wichman, Punyasha Roul, Scott M. Matson, Jorge Díaz, Jianghu Dong, Joshua F. Baker, Tate M. Johnson, Michael George, Brian C. Sauer, Ted R. Mikuls, Bryant R. England, Yangyuna Yang, Grant W. Cannon, Halie Frideres
article en
7 citations

Abstract

We did not find significant differences in mortality or respiratory hospitalization between RA-ILD patients initiating different non-TNFi b/tsDMARDs, though estimates were imprecise, and residual confounding may be present. These findings emphasize the need for clinical trials of advanced immunomodulatory therapies in RA-ILD.

Seminars in Arthritis and RheumatismVol. 73
Nebraska Medical Center (US), University of Alabama at Birmingham (US), VA Salt Lake City Healthcare System (US), VA Puget Sound Health Care System (US), University of Kansas Medical Center (US), Philadelphia VA Medical Center (US), VA Nebraska Western Iowa Health Care System (US), University of Nebraska Medical Center (US), University of Pennsylvania (US)
Good health and well-being
Openalex Percentile: Top 2%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
10.63
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