Genomic and Developmental Models to Predict Cognitive and Adaptive Outcomes in Autistic Children
Results of this prognostic study suggest that the growing number of neurodevelopmental condition-associated variants cannot, in most cases, be used alone for predicting ID. However, models combining different classes of variants with developmental milestones provide clinically relevant individual-level predictions that could be useful for targeting early interventions.
Authors
- Guy A. Rouleau (ORCID: https://orcid.org/0000-0001-8403-1418)
- Varun Warrier (ORCID: https://orcid.org/0000-0003-4532-8571)
- Aurélie Labbe (ORCID: https://orcid.org/0000-0002-4207-8143)
- Zohra Saci (ORCID: https://orcid.org/0000-0003-2788-1306)
- Richard A. I. Bethlehem (ORCID: https://orcid.org/0000-0002-0714-0685)
- Guillaume Huguet (ORCID: https://orcid.org/0000-0002-4746-6030)
- Simon Baron‐Cohen (ORCID: https://orcid.org/0000-0001-9217-2544)
- Laurent Mottron (ORCID: https://orcid.org/0000-0001-5668-5422)
- Jacob Vorstman (ORCID: https://orcid.org/0000-0002-1677-3126)
- Adeniran Okewole (ORCID: https://orcid.org/0000-0003-1670-8516)
- Martineau Jean‐Louis (ORCID: https://orcid.org/0000-0002-3305-3307)
- Jade England
- Thomas Rolland (ORCID: https://orcid.org/0000-0001-6468-8391)
- Zoe Schmilovich
- Thomas Renne (ORCID: https://orcid.org/0000-0002-1401-1806)
- Xinhe Zhang (ORCID: https://orcid.org/0000-0002-5930-2738)
- Vincent-Raphaël Bourque (ORCID: https://orcid.org/0000-0001-9420-1724)
- Cécile Poulain (ORCID: https://orcid.org/0000-0002-5371-1581)
- Sébastien Jacquemont
Institutions
- HEC Montréal (CA)
- Montreal Neurological Institute and Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- Institut Pasteur (FR)
- University of Toronto (CA)
- University of Cambridge (GB)
- Hospital for Sick Children (CA)
- McGill University Health Centre (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- SickKids Foundation (CA)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal (CA)
- Hôpital Rivière-des-Prairies (CA)
- Centre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-Montréal
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- JAMA Pediatrics
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1001/jamapediatrics.2025.0205
- Citations
- 6
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 8.59