Skin Cancer Cutaneous Squamous Cell

Abstract: Usually due to UV light-induced DNA damage, keratinocytes in the epidermis proliferate abnormally, resulting in cutaneous squamous cell carcinoma (cSCC). Histological assessment is still the gold standard for identifying cSCC, but modern optical imaging diagnostic techniques enable doctors to perform "optical or virtual biopsy" in real time. Presenting a current literature review and advancements in optical imaging diagnostics for cSCC is our aim. Papers published between 2008 and 2022 were thoroughly evaluated using the PubMed, Embase, and Cochrane databases. Out of the 9581 total articles that the search yielded, 136 relevant articles that satisfied screening and eligibility criteria were included in the literature evaluation. This paper highlights the optical imaging techniques currently used to diagnose cSCC. The most recent advances in nonsurgical care of SCC were reviewed, despite the fact that surgical excision or Mohs micrographic surgery is still regarded as the gold standard. The review of the literature leads us to the conclusion that modern optical imaging tools, including multiphoton tomography, optical coherence tomography, line-field confocal optical coherence tomography, and confocal microscopy, have transformed real-time diagnostic imaging in dermatology, especially in the field of skin cancer. Rapid diagnosis and therapy beginning are made possible by these gadgets. Patients with multifocal cSCC, for whom many biopsies would be impractical, or high-risk patients (such as those who have received organ transplants or are exposed to prolonged UV radiation) may benefit from the use of modern imaging technologies in the management of cSCC, therefore avoiding needless biopsies. Optical imaging technology, in conjunction with dermoscopy, can enhance diagnostic efficiency by decreasing turnaround time