Ganoderic acid a potentiates cisplatin’s cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness
GAA can significantly enhance the anticancer effects of DDP on GBC cells by inhibiting DNA damage response and cell stemness, supporting GAA as an adjuvant treatment for GBC and warrants further validatory preclinical studies.
Authors
- Meng Zhou (ORCID: https://orcid.org/0000-0003-2688-0889)
- Haoming Lan
- Jie Wu (ORCID: https://orcid.org/0000-0003-2321-1866)
- Xiang Sheng
- Linsheng Huang
- Gan Zhang (ORCID: https://orcid.org/0000-0002-9010-8140)
- Jun Hu (ORCID: https://orcid.org/0009-0008-5619-7742)
Institutions
- Hubei University of Medicine (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s12957-025-03799-x
- Citations
- 3
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 2.42