Systems genetics uncovers associations among host amylase locus, gut microbiome, and metabolic traits in mice
This work reveals novel relationships among host genetic variation, gut microbial enterotypes, and host metabolic traits and supports the notion that variation of host amylase may represent a key determinant of gut microbiome in mice. Video Abstract.
Authors
- Mark P. Keller (ORCID: https://orcid.org/0000-0002-7405-5552)
- Federico E. Rey (ORCID: https://orcid.org/0000-0002-0239-7780)
- Evan R. Hutchison (ORCID: https://orcid.org/0000-0003-3251-0120)
- Aldons Jake Lusis (ORCID: https://orcid.org/0000-0001-9013-0228)
- Matthew F Warren (ORCID: https://orcid.org/0000-0002-6309-584X)
- Calvin Pan (ORCID: https://orcid.org/0000-0002-0752-833X)
- Alan Attie (ORCID: https://orcid.org/0000-0002-0568-2261)
- Qijun Zhang (ORCID: https://orcid.org/0000-0002-1003-7355)
Institutions
- University of Wisconsin–Madison (US)
- University of California, Los Angeles (US)
Publication Details
- Journal
- Microbiome
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s40168-025-02093-y
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- University of Wisconsin-Madison
- Fondation Leducq
- National Institutes of Health