Abstract 4030: Uncovering psychosocial and physical challenges in colorectal cancer: findings from a comprehensive patient and survivor survey

Abstract Background: Colorectal cancer (CRC) is the third most diagnosed cancer and the second leading cause of cancer-related deaths globally among men and women combined. While survival rates for CRC have improved, limited knowledge exists about the specific unmet needs of CRC patients and survivors. These needs include emotional support, information on treatment options, and strategies for coping. CRC significantly impacts patients' emotional well-being, quality of life (QoL), and healthcare experiences. Beyond the stress of a cancer diagnosis, patients endure the physical and emotional toll of rigorous treatments, even in cases where no signs of the disease remain. Methods: The Colorectal Cancer Alliance conducted a comprehensive survey of CRC patients, survivors, and caregivers to better understand their experiences and needs. This IRB-approved, cross-sectional study included over 150 questions addressing patient profiles, diagnosis, access to care, treatment experiences, resources, and QoL. The survey was distributed through the Alliance’s social media, email, and web-based platforms, reflecting a collaborative effort to address the multifaceted challenges faced by the CRC community. Results: Insights from 283 CRC patients and survivors highlighted critical unmet needs. The median age group of respondents was 46-55. Key findings included 74% struggling to find someone who shared similar experiences, 41% reporting reduced support after treatment, 54% feeling fatigued, and 51% experiencing stress. Cancer significantly disrupted personal and social aspects of life: 64% reported adverse effects on careers, 51% on dating, 43% on family planning, 58% on spousal relationships, 80% on sexual health, and 65% on social participation. Although patients felt well-informed pre-treatment, 46% identified gaps in knowledge about complementary or alternative therapies. These findings underscore the importance of addressing psychosocial and physical needs to improve care outcomes. Conclusions: CRC patients and survivors face profound psychosocial and physical challenges that reshape their lives. By identifying these needs, healthcare providers can develop more personalized treatment plans and support systems, offering hope for better patient experiences and outcomes. The Alliance aims to use these findings to guide clinical practices, care programs, and survivorship support, driving transformative improvements in CRC care. Citation Format: Kimberly Lynn Newcomer, David Fenstermacher. Uncovering psychosocial and physical challenges in colorectal cancer: findings from a comprehensive patient and survivor survey [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 4030.