Abstract 3350: Prognostic importance of physical activity in the chemotherapy of esophagogastric cancer; associations with skeletal muscle, systemic inflammation, and lifestyle

Abstract Background: Physical activity (PA) must be an important intervention in the treatment of cancer. However, it is unknown what kinds of PAs can improve patients’ outcome in the chemotherapy of esophagogastric cancer (EGC). Methods: Unresectable or recurrent EGC patients treated with chemotherapy were prospectively investigated. PA was measured using an accelerometer for 1 week before and after the chemotherapy administration. PA was classified as sedentary behavior (< 1.5METs, SB), light-intensity PA (1.6-2.9 METs, LPA), and moderate-to-vigorous PA (≥ 6.0 METs, MVPA). PA parameters were compared with disease specific survival (DSS), inflammatory and nutritional markers, subsequent skeletal muscle (SM) volume change, and lifestyle. Results: Thirty-nine patients were evaluated. In Cox regression analyses, better DSS was significantly correlated with longer times of LPA (P=0.02), but not with MVPA (P=0.2). LPA showed significant negative correlations with WBC, CRP, and modified GPS score (P=0.03, 0.03, 0.004, respectively), and positive correlations with serum total protein (TP) and albumin (Alb) levels and SM change (P=0.01, 0.003, 0.01, respectively). The longer times of LPA was significantly associated with better socialization with neighbors (P=0.001). Conclusions: LPA would be recommended during the chemotherapy of advanced EGC patients, keeping their better inflammatory and nutritional status and preventing SM loss. Socialization might play a key role in increasing LPA. Citation Format: Koichi Hayano, Natsiko Arimatsu, Yasunori Matsumoto, Yoshihiro Kurata, Ryota Otsuka, Akira Nakano, Tadashi Shiraishi, Nobufumi Sekino, Takeshi Toyozumi, Masaya Uesato, Gaku Ohira, Hisahiro Matsubara. Prognostic importance of physical activity in the chemotherapy of esophagogastric cancer; associations with skeletal muscle, systemic inflammation, and lifestyle [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 3350.