Abstract 4020: Review of literature on the effect of stress and anxiety among African-American breast and endometrial cancer patients

Abstract African American women face disproportionately higher rates of breast and endometrial cancer recurrence compared to their Caucasian counterparts, highlighting an urgent need to explore the role of stress in cancer progression and recurrence. This study conducts a systematic review of the literature to evaluate the efficacy of stress and anxiety interventions in reducing cancer risk among African American survivors. By analyzing 25 articles from 2014-2024, this review examines the correlation between psychological stress, biological stress markers, and cancer outcomes. The findings emphasize the significant impact of stress on health outcomes, particularly in the context of cortisol's role in metabolism and immune response. The review also explores coping mechanisms, including social support, diet, and exercise, tailored to African American women's cultural and socioeconomic needs. The results underscore the critical need for targeted interventions to address stress in this population, with implications for improving cancer survivorship and advancing healthcare equity. Citation Format: Gabrielle Ford, Zakirah L. Abdul-Hameed, Amirah Burton, Brian M. Rivers, Desiree Rivers. Review of literature on the effect of stress and anxiety among African-American breast and endometrial cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 4020.