Abstract 4018: Primary gallbladder cancer association with cardiovascular mortality: A 20 year population-based retrospective study

Abstract Introduction: Primary gallbladder cancer (PGC) is the most common cancer of the biliary system. It is often late presenting, leading to a poor prognosis. While evolution and progress in medicine have resulted in reduced mortality rates in PGC, non-cancer deaths are at an increasing trend. Cardiovascular mortality (CVM) plays a significant role in this trend. We holistically evaluated the CVM risk in patients with PGC. Methods: We utilized the Surveillance, Epidemiology, and End Results (SEER) database to retrieve PGC patients with CVM from 2000-2021. CVM was defined as death from diseases of the heart, hypertension without heart disease, cerebrovascular diseases, atherosclerosis, aortic aneurysm and dissection, and other diseases of arteries, arterioles and capillaries. We then obtained the standardized mortality rates (SMR) and absolute excess risk (AER). Results: Total number of PGC patients who died from cardiovascular diseases was 706. Patients with non-cardiovascular causes of death and patients with unknown age, race and cancer stage were excluded. We compared the cardiovascular disease (CVD) mortality risk of each group to the general US population and noted significantly increased CVD SMRs. Regarding race, Asians or Pacific Islanders had the highest risk of CV mortality (SMR 6.80, CI 5.10-8.87, p < 0.05), followed by Blacks (SMR 6-15, CI 4.88-7.66, p < 0.05), then American Indians/Alaska Natives (SMR 5.89, CI 1.60-15.08, p < 0.05) and Whites (SMR 3.99, CI 3.67-4.33, p < 0.05). Based on cancer stage, distant had the highest risk of CV mortality (SMR 17.79, CI 14.62-21.44, p < 0.05) while localized had relatively the lowest risk (SMR 3.10, CI 2.59-3.69, p < 0.05) with regional being (SMR 4.52 CI 4.00-5.08, p < 0.05). In terms of age, patients aged 40-59 years had an SMR of 20.89 (CI 15.65-27.33, p < 0.05), 60-79 years had an SMR of 5.14 (CI 4.60-5.74, p < 0.05), while 80 years and above had an SMR of 3.34 (CI 2.99-3.72, p < 0.05). Conclusion: Our analysis examines the magnitude of CVD-related deaths in PGC patients. Compared to the general United States population, patients with PGC have a higher risk of cardiovascular mortality. Therefore, patients with PGC should be screened for CVD to provide more holistic care in this patient population. Citation Format: Oboseh J. Ogedegbe, Olanipekin Ntukidem, Asfand Y. Cheema, Sakshi Bai, Kai He, Utkarsh Acharya. Primary gallbladder cancer association with cardiovascular mortality: A 20 year population-based retrospective study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 4018.