Single-cell RNA sequencing reveals a reprogramming of hepatic immune cells and a protective role for B cells in MASH-driven HCC
Our findings reveal a complex immune reprogramming within the metabolic dysfunction-associated steatohepatitis-driven HCC microenvironment and underscore a protective role for B cells in liver cancer. These results highlight B cells as potential targets for immunomodulatory therapies in HCC.
Authors
- Davis Seelig (ORCID: https://orcid.org/0000-0002-1733-8177)
- Fanta Barrow (ORCID: https://orcid.org/0000-0002-6025-1210)
- Adam Herman (ORCID: https://orcid.org/0000-0001-7463-9462)
- Sayeed Ikramuddin (ORCID: https://orcid.org/0000-0003-3088-7952)
- Xavier S. Revelo (ORCID: https://orcid.org/0000-0002-2754-509X)
- Gavin Fredrickson (ORCID: https://orcid.org/0000-0002-4219-1947)
- Haiguang Wang (ORCID: https://orcid.org/0000-0001-5403-9179)
- Preethy Parthiban (ORCID: https://orcid.org/0000-0002-0132-9970)
- Micah Draxler
- A. A. Abdelghani
Institutions
- University of Minnesota (US)
- University of Minnesota Medical Center (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1097/hc9.0000000000000668
- Citations
- 7
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.58