Natural anti-neuroinflammatory inhibitors from <i>Aglaia odorata</i>
Eleven compounds were isolated from the <i>n</i>-butanol extract of <i>Aglaia odorata</i> Lour, including one undescribed lignan, curlignan-4-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>1</b>), and ten known compounds (<b>2-11</b>). Their structures were characterized by comprehensive spectral analysis, nuclear magnetic resonance (1D and 2D NMR), mass spectrometry (MS), and electronic circular dichroism (ECD). The inhibitory effects of these compounds on nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated BV-2 microglia were evaluated. The experimental results indicated that the anti-neuroinflammatory activities of compounds <b>1, 3, 4, 6, 7, 9</b> and <b>10</b> were significantly better than those of the positive control minocycline (IC<sub>50</sub> = 41.34 ± 3.55 μM), with IC<sub>50</sub> values ranging from 1.31 to 15.70 μM.
Authors
- Qianqian Yin (ORCID: https://orcid.org/0000-0002-8403-0236)
- Qingqi Meng (ORCID: https://orcid.org/0000-0002-0233-9046)
- Mingxia Fang
- Di Zhou
- Zhao Chen (ORCID: https://orcid.org/0000-0002-6840-316X)
- Ning Li (ORCID: https://orcid.org/0000-0002-6518-2541)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-9155-8979)
- Yanping Zhang (ORCID: https://orcid.org/0000-0002-8218-3431)
- Yue Hou
- Xin‐Yang Liu
Institutions
- Shenyang Pharmaceutical University (CN)
- Northeastern University (US)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1080/10286020.2025.2492355
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China