Polyprenylated acylphloroglucinols from <i>Hypericum attenuatum</i> and their antidepressant activities
Three new polycyclic polyprenylated acylphloroglucinols, attenuatumines A-C (<b>1-3</b>), were ioslated from the 90% EtOH extract of the air dried aerial parts of <i>Hypericum attenuatum</i>. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy. All the isolated compounds were evaluated for their antidepressant activity by inhibiting reuptake of tritiated serotonin ([<sup>3</sup>H]-5-HT) and noradrenalinet ([<sup>3</sup>H]-NE) in rat brain synaptosomes. Compounds <b>2</b> exhibited some antidepressant activities in the [<sup>3</sup>H]-5-HT mode.
Authors
- Yong Xiang (ORCID: https://orcid.org/0000-0001-5757-9023)
- Enhui Zhang (ORCID: https://orcid.org/0000-0003-3345-8934)
- Dan Liu (ORCID: https://orcid.org/0000-0001-8906-6361)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1080/10286020.2025.2492351
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00