Abstract 2264: Disparities in perceptions and uptake of genetic testing among the United States population: trends from 2011-2022

Background: Over the last decade, genetic testing has become more readily available, but it is not known whether this has translated to greater public awareness and usage over time. We aimed to evaluate patterns and temporal trends in genetic testing awareness and usage, along with their sociodemographic and cancer history correlates, in the United States (US) population. Methods: We performed a serial, cross-sectional analysis of nationally representative data from the National Cancer Institute’s Health Information National Trends Survey (HINTS). We analyzed survey responses from adults aged 18 or older from HINTS 4 Cycle 1 (2011), 4 Cycle 2 (2012), 4 Cycle 3 (2013), 4 Cycle 4 (2014), 5 Cycle 1 (2017), 5 Cycle 4 (2020), 6 (2022). Crude linear trend was evaluated using a linear regression model and multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CIs). Results: Data on 22,256 individuals (mean [SD] age, 46.7 [17.0] years; 13,208 (50.7%) female; non-Hispanic White 13,559 (65.2%)) were analyzed from 2011-2022 HINTS data. Awareness of genetic testing increased from 36.6% in 2011 to 81.7% in 2022 (p<0.001). Older adults, men, non-Hispanic Black individuals, non-Hispanic Asian individuals, Hispanic individuals, those with an education level less than some college, and individuals with annual household incomes less than $75,000 were significantly less likely to be aware of genetic testing. Uptake of genetic testing, however, lagged behind awareness with rates of 21.4% in 2020 and 35.6% in 2022. Uptake of genetic testing was significantly lower among non-Hispanic Asian individuals, those with household incomes under $35,000, and those without a personal history of cancer. Conclusion: Despite high levels of awareness, genetic testing uptake remains disproportionately low, with notable disparities across sociodemographic groups. Targeted educational interventions focused on genetic testing are necessary for marginalized populations and the providers caring for them. Further study is needed to understand genetic testing uptake patterns in the US. Citation Format: Ariana Naaseh, Mengyao Shi, Steven Tohmasi, Erin L. Linnenbringer, Julie A. Margenthaler, Graham A. Colditz, Yin Cao. Disparities in perceptions and uptake of genetic testing among the United States population: trends from 2011-2022 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 2264.