Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells
Ubiquitination and ADP-ribosylation are protein post-translational modifications (PTMs) which influence diverse protein properties. In vitro work has indicated that ubiquitin can be ADP-ribosylated and vice versa, ADP-ribose ubiquitinated. An exciting new study by Bejan et al. now demonstrates that ubiquitination of ADP-ribosylated proteins, termed MARUbylation, occurs in human cells.
Authors
- Karla L. H. Feijs (ORCID: https://orcid.org/0000-0002-8074-2180)
- Roko Žaja (ORCID: https://orcid.org/0000-0003-3944-0153)
- Jonas Siefert
Institutions
- RWTH Aachen University (DE)
Publication Details
- Journal
- Trends in Biochemical Sciences
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.tibs.2025.03.010
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00