An Autonomously Liquefied Hydrogel Adhesive for Programmable Bioelectronic Interface

Abstract Hydrogel adhesives have many important applications in the fields of drug delivery, regenerative medicine, and bioelectronics. The detachment of hydrogel adhesives under the benign conditions is vital to the definitive surgical repair and implanted devices. Although stimuli‐mediated detachment of hydrogel adhesives has been achieved, it is still a grand challenge to develop a transient adhesive with programmable adhesion and autonomous detachment from the substrate, especially the hairy skins. Here, we report a transient hydrogel adhesive driven by antagonistic enzyme reaction networks for programmable bioelectronic interface. The transient hydrogel shows tunable mechanical properties, adjustable adhesive strength, and autonomous sol‐gel‐sol transition with a programmable lifetime. Moreover, the transient hydrogel adhesive enables conformable and stable adhesion to various materials. In particular, the bioelectrode coated by the transient hydrogel adhesive allows to record stable and high‐quality electromyogram, electrocardiogram, and electroencephalogram signals directly on the hairy skins without hair shaving. Notably, the autonomous liquefication of the hydrogel adhesives enables the easy removal of bioelectrode from hairy skins after usage without any noticeable damages to the hairy skins and electrode. This work paves a new avenue in the innovative development of hydrogel adhesives for the conformable and detachable bioelectronic interface.