Abstract 595: CMOS sensor-based micro-dosimetry for radiation theranostics: A novel approach

CMOS Sensor based micro-dosimetry allowing measuring radiation tracks at micron level by the track structure detector (TSD) have been established by us with 1.67 micron / pixel resolution. In radiation theranostics, individual organ dosimetry is critical for predicting absorbed doses to normal organs and target tissue in terms of therapeutic efficacy and toxicity reduction with radiopharmaceutical therapy. We designed and applied our well characterized micro dosimetry system utilizing a CMOS (complementary metal oxide)-based radiation Track Structure Detector (TSD) device to analyze radiation quality and quantity from different forms of radiation and radiopharmaceutical drugs. The TSD system allowed capturing and analyzing heavy ion tracks at cellular dimensions with a 1.67 microns per pixel resolution and more than 10 M pixels on a 0.6 cm x 0.4 cm sensor. Further towards individualized radiopharmaceutical treated patients, we propose Integrated Wearable Micro Dosimetry for Remote Monitoring-VASTRA. Here, we demonstrate the capability to objectively detect, measure, and spatially resolve the imaging radiation activity of radiopharmaceutical therapeutic radionuclides including 18F-FDG, TC99m and validates the VASTRA in a smart phantom. Consequently, the approach is capable to measure patient-specific temporal activity data in radiopharmaceutical therapy. As an integrated ergonomical wearable dosimetry, VASTRA in Post cancer treatment, has unique opportunities and a profound impact on the quality assurance in the cancer treatment. Citation Format: Rao V. Papineni, Prem Saganti, Huichen Wang, Rahman M. CMOS sensor-based micro-dosimetry for radiation theranostics: A novel approach [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 595.