Causal relationship between gastroesophageal reflux disease and the risk of chronic suppurative otitis media: a mendelian randomization analysis
For the first time, GERD was identified as a risk factor for CSOM through a bidirectional MR study. This finding provides high-level causal evidence for the prevention and management of CSOM and forms a basis for future clinical and mechanistic studies. Clinicians should consider the potential impact of GERD when treating patients with CSOM, as GERD may be an important risk factor.
Authors
- Xiaowen Zhang (ORCID: https://orcid.org/0000-0001-8398-8920)
- Tao Fu (ORCID: https://orcid.org/0000-0002-6900-5518)
- Shenling Li
- Kaichun Wu (ORCID: https://orcid.org/0000-0002-0699-9666)
- Qiwen Zheng (ORCID: https://orcid.org/0000-0001-6921-6254)
- Y. X. Li (ORCID: https://orcid.org/0000-0003-2236-6794)
- Wenrui Tang (ORCID: https://orcid.org/0000-0001-7353-3033)
- Siyu Ren (ORCID: https://orcid.org/0009-0006-9958-713X)
- Ce Wu (ORCID: https://orcid.org/0000-0002-6447-0365)
- Qiuying Zhu (ORCID: https://orcid.org/0000-0001-6438-6828)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- SAGE Open Medicine
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1177/20503121251332151
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00