Pharmacological aspects of Isabgol: An overview

Pharmacological aspects of Isabgol: An overview - Herbal medicine is widely used globally, including in India, where it plays a significant role in primary health care. It is alternatively known as Ispaghula Psyllium, Plantago ispaghula, and Plantago ovata. Psyllium offers numerous health benefits.2 Psyllium is a naturally occurring, hydrophilic gel-forming substance that has been historically utilized in China and India for an herbal remedy for various ailments. These include bladder issues, high blood pressure, skin irritations, constipation, diabetes mellitus, ulcerative colitis, haemorrhoids, cholesterol reduction, colorectal cancer, hyperlipidaemia, hyperuricemia, and anti-ulcer activity.1 Plantago is a valuable botanical remedy containing various compounds such as phenolic, flavonoids, alkaloids, terpenoids, and vitamin C.42 Its phenolic compounds, including flavonoids, provide the plant with antioxidant properties, while these phenolic also offer protection against UV radiation.5 This review examines its bioactive components and their modes of action, shedding light on the therapeutic benefits of Isabgol in supporting gastrointestinal health, cardiovascular function, and metabolic balance. Research highlights its prebiotic capabilities and effectiveness in addressing conditions such as constipation, diarrhoea, and irritable bowel syndrome through gut micro biota modulation and improved stool quality. Additionally, Isabgol's blood sugar-lowering and cholesterol-reducing effects play a vital role in the management of diabetes and cardiovascular disorders. Its applications in weight regulation, skincare, and emerging cancer research further underscore its adaptability. This review highlights the importance of Isabgol in integrative medicine, offering a detailed evaluation of its pharmacokinetics, bioavailability, and safety profile for medical use.1 Keywords: Plantago Ovata, Anti-carcinogenic, Anti-inflammatory, Anti-oxidant, Drug delivery agent, Botanical remedy.