Exploring the Comorbidity Mechanism among Functional Diarrhea,Irritable Bowel Syndrome with Predominant Diarrhea, and FunctionalDyspepsia through the Gut-brain Axis and the PharmacologicalMechanisms of Shen-Ling-Bai-Zhu-San Therapy

This study elucidates potential targets shared by FDr, IBS-D, and FD through the gut-brain axis, highlighting diosgenin's interaction with PTGS2 as a potential mechanism of SLBZS's therapeutic effects. These findings provide valuable insights into the pharmacological mechanisms of SLBZS in treating FGIDs and suggest new avenues for targeted therapies.