Shiff Base Metal Complexes Of Cu (II), Ni(II), and Zn(II) Drived From 2-Hydroxy Acetophenone and O-Phenylenediamine; Synthesis, Characterization, Antimicrobial and Molecular Docking

Conductivity measurements, magnetic measurements, spectroscopic analysis, anti-bacterial, and molecular docking activities have been used to manufacture and analyse Cu(II), Ni(II), and Zn(II) Schiff base metal complexes generated from 2-Hydroxyacetophenone and O-phenylenediamine. The Schiff base's infrared spectra showed an azomethine peak at 1640 cm-1. The complexes' shifting of this band to higher or lower wave numbers suggested that the azomethine nitrogen was involved in coordination (M-N). New bands at 758-762 cm-1 in metal complexes have been attributed to the υ(M-N) mode. New bands at 660–700 cm-1 in metal complexes indicate the presence of the υ(M-O) mode. Metal complexes exhibit new bands at 3300-3200 cm-1 that are associated with the υ(OH) mode. Measurements of conductance (1.64 to 30.50 Ohm-1 cm2 mol-1) indicated that none of the complexes were electrolytic. Both the 1.9 B.M. (Cu (II)) and 3.6 B.M. (Ni (II)) magnetic susceptibility values are consistent with square planar geometry, and the metal-ligand ratio was verified as 1:1 using Jobs' method of continuous variation. The antimicrobial activity of the Schiff base and its metal chelates was tested against six pathogenic microorganisms (Escherichia coli, Candida albican, Mucor indicus, and Staphyloccus aureus). The complexes exhibited higher antimicrobial activity against the tested microbes, while the Schiff base exhibited moderate activity. The anti-cancer medication Tamoxifen was less effective than the complexes and ligand against human breast cancer cells (HER2-PY1196 4GFV).