Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis
hUC-MSC-derived exosomal miR-199a-3p alleviates OA by inhibiting the mitogen-activated protein kinase 4/nuclear factor-kappaB signaling pathway. The present findings suggest that miR-199a-3p delivery by hUC-MSC-Exos may be a novel strategy for the treatment of OA.
Authors
- Xia He (ORCID: https://orcid.org/0000-0002-7314-1002)
- Zi-Jing Yin (ORCID: https://orcid.org/0000-0001-9918-0766)
- Weijuan Huang (ORCID: https://orcid.org/0000-0002-8655-130X)
- Sha Ma (ORCID: https://orcid.org/0000-0002-0672-6502)
- Hongxia Peng (ORCID: https://orcid.org/0000-0001-9998-6284)
- Xiaoqing Shi (ORCID: https://orcid.org/0000-0002-3675-7326)
- Dachen Zuo
- Jing Wang (ORCID: https://orcid.org/0000-0002-2199-9496)
- Qin Li (ORCID: https://orcid.org/0000-0002-2470-6089)
- Juan Yu (ORCID: https://orcid.org/0000-0003-2706-906X)
- Lingqiang Chen (ORCID: https://orcid.org/0000-0003-3765-4270)
- F. Li
Institutions
- Kunming Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-04-21
- DOI
- https://doi.org/10.4252/wjsc.v17.i4.103919
- Citations
- 8
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 13.34