L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases
L-arginine is important for inducing therapeutic angiogenesis for ADSCs and BMSCs in hypoxic conditions. ADSCs have higher L-arginine secretion, which leads to better angiogenesis induction and cardiac protection. ADSC transplantation is a promising autologous cell therapy strategy in the context of the present aging society.
Authors
- Kai Kang (ORCID: https://orcid.org/0000-0002-9802-2309)
- Zhan Xu (ORCID: https://orcid.org/0000-0003-1224-9789)
- Wenxi Zhang (ORCID: https://orcid.org/0000-0002-8863-4838)
- Chao Chi (ORCID: https://orcid.org/0000-0001-5901-5061)
- Guofu Zhang (ORCID: https://orcid.org/0000-0002-6715-5520)
- Haobo Sun (ORCID: https://orcid.org/0000-0001-6281-6281)
- Jianzhong Li
- Donghui Liu (ORCID: https://orcid.org/0000-0002-5963-5372)
- Sun Li-hua
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Education Department of Heilongjiang Province (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-04-21
- DOI
- https://doi.org/10.4252/wjsc.v17.i4.103314
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.63