Efficient gene transfer by pulse parameters for electrochemotherapy of cells <i>in vitro</i> and in muscle and melanoma tumors in mice
Our study demonstrated the efficient transfection of tumors and muscles with the GET4 pulse protocol, which is used clinically for electrochemotherapy. The use of this protocol could enable simultaneous electrochemotherapy and GET of the therapeutic gene in one session, which will significantly shorten the procedure and thus will be more tolerable for patients.
Authors
- Boštjan Markelc (ORCID: https://orcid.org/0000-0002-8674-702X)
- Simona Kranjc (ORCID: https://orcid.org/0000-0003-0538-7841)
- Gregor Serša (ORCID: https://orcid.org/0000-0002-7641-5670)
- Maša Omerzel
- Maja Cemazar
Institutions
- University of Primorska (SI)
- University of Ljubljana (SI)
- Institute of Oncology Ljubljana (SI)
Publication Details
- Journal
- Radiology and Oncology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.2478/raon-2025-0027
- Citations
- 2
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.47