CFD modeling of blood flow in myeloid sinusoidal capillaries

The bone marrow microcirculatory system's present challenges for experimental investigation due to its complexity and limited accessibility. This study employs Computational Fluid Dynamics (CFD) to model blood flow within the myeloid sinusoidal capillaries of mice femur bone, focusing on velocity profiles, pressure distributions, and wall shear stresses. Using ANSYS Fluent 2023 R2, a detailed computational domain was developed from microscopic focus-stacked images, with a robust unstructured mesh applied for precise flow simulations. Blood was modeled as a multiphase Eulerian mixture, accounting for plasma and red blood cell dynamics. Results were validated against experimental data, showing a good agreement in velocity, volume fractions, and wall shear stress distributions. These findings underline the capability of CFD in providing detailed insights into microvascular blood flow, supporting future studies on hematological disorders and bone marrow mechanics.