Buffer 4‐Ethylmorpholinium/Acetate: Exploring a New Alternative Buffer for Native Mass Spectrometry
We introduced 4EM/A, with pK<sub>a</sub> of 7.72/4.76, as a promising buffer for native-MS studies to maintain protein and protein complex bioactivity and conformational integrity.
Authors
- Yuandi Zhao (ORCID: https://orcid.org/0000-0001-5376-140X)
- Tiffany Porta Siegel (ORCID: https://orcid.org/0000-0001-5454-1863)
- Eva Cuypers (ORCID: https://orcid.org/0000-0002-6411-2461)
- Anjusha Mathew (ORCID: https://orcid.org/0000-0003-0138-4600)
- C Y Ng
- Ian G. M. Anthony (ORCID: https://orcid.org/0000-0003-0433-8343)
- Berta Cillero‐Pastor (ORCID: https://orcid.org/0000-0002-7407-1165)
- Darya Hadavi (ORCID: https://orcid.org/0000-0003-3998-8127)
- Maarten Honing (ORCID: https://orcid.org/0000-0001-7180-6245)
Institutions
- Maastricht University (NL)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1002/rcm.10048
- Citations
- 1
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.76
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Maastricht Universitair Medisch Centrum