Associations of Hysterectomy, Oophorectomy, and Hormone Replacement Therapy With the Risk of Type 2 Diabetes Mellitus in Postmenopausal Women
Hysterectomy, regardless of bilateral oophorectomy status, was associated with a higher risk of T2DM. The HRT use, particularly early use in women without surgical interventions, was associated with a high risk. Our findings indicate that female-specific risk factors such as hysterectomy and bilateral oophorectomy and HRT use should be incorporated into the assessments for potential risk of T2DM in postmenopausal women.
Authors
- Xinyue Yu (ORCID: https://orcid.org/0000-0001-5356-5177)
- Yingru Li (ORCID: https://orcid.org/0000-0002-3258-9230)
- Xiong‐Fei Pan (ORCID: https://orcid.org/0000-0002-9350-9230)
- Yunhaonan Yang
- Nianwei Wu
- Peiqi Zhang (ORCID: https://orcid.org/0000-0001-7649-6338)
- Tianlei Wang (ORCID: https://orcid.org/0000-0002-4498-4326)
- Ying Hu (ORCID: https://orcid.org/0000-0002-3904-1649)
- Shuo Li (ORCID: https://orcid.org/0000-0003-2331-2448)
- Jingyi Li (ORCID: https://orcid.org/0000-0001-6822-7998)
- Rui Li (ORCID: https://orcid.org/0000-0002-2379-5219)
- Fan Li (ORCID: https://orcid.org/0000-0002-7481-0394)
- Qingping Xue (ORCID: https://orcid.org/0000-0001-6166-2313)
- Qingqing Ouyang
- Yidan Dong
Institutions
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
Publication Details
- Journal
- Clinical Endocrinology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1111/cen.15253
- Citations
- 1
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province
- Fundamental Research Funds for the Central Universities