Histology-Specific Treatment Strategies and Survival Prediction in Lung Cancer Patients with Spinal Metastases: A Nationwide Analysis
The management of spinal metastases requires a histology-specific approach. Radiation remains the primary treatment, with SBRT predicting better short- and long-term survival. High-dose radiation and reirradiation should be considered for NSCLC, while the benefits are limited in SCLC. These findings support histology-specific treatment strategies to improve survival of patients with metastatic lung cancer to the spine.
Authors
- Daniel Lubelski (ORCID: https://orcid.org/0000-0002-9403-9509)
- Kristin J. Redmond (ORCID: https://orcid.org/0000-0003-3442-4613)
- Meghana Bhimreddy (ORCID: https://orcid.org/0000-0001-7570-4094)
- Joshua Weinberg (ORCID: https://orcid.org/0000-0002-3464-5697)
- Arjun K. Menta (ORCID: https://orcid.org/0000-0002-6371-6052)
- Abdul Karim Ghaith (ORCID: https://orcid.org/0000-0002-9600-609X)
- Taha Khalilullah (ORCID: https://orcid.org/0000-0002-1257-3987)
- Jawad M. Khalifeh (ORCID: https://orcid.org/0000-0002-5726-6884)
- Melanie Alfonzo Horowitz (ORCID: https://orcid.org/0000-0002-4935-7268)
- Ali Ahmed (ORCID: https://orcid.org/0000-0003-4476-2384)
- Abdel‐Hameed Al‐Mistarehi (ORCID: https://orcid.org/0000-0003-4713-8536)
- Chase H. Foster (ORCID: https://orcid.org/0000-0003-2637-2331)
- Nicholas Theodore (ORCID: https://orcid.org/0000-0001-5355-2683)
- Xinlan Yang
- Xihang Wang (ORCID: https://orcid.org/0009-0003-1960-9772)
- Tej Azad
Institutions
- Johns Hopkins University (US)
- George Washington University (US)
- Johns Hopkins Medicine (US)
- The Ohio State University (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-04-21
- DOI
- https://doi.org/10.3390/cancers17081374
- Citations
- 1
- Primary Topic
- Management of metastatic bone disease
- Type
- article
- Field-Weighted Citation Impact
- 2.01