The association between pulse wave velocity and cerebrospinal fluid biomarkers for Alzheimer's disease
We examined the association between arterial stiffness using non-invasive pulse wave velocity (PWV) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. We conducted a cross-sectional multivariate logistic regression analysis using established cut-off values for PWV and CSF biomarkers. Of the 739 participants, 69% were female, 84% were White, 12% were Black, and the mean age was 62. After adjustment for potential confounders, participants with high PWV had 94% (OR = 1.94, 95% CI 1.20-3.20) greater odds of AD biomarker positivity for tTau/Aβ<sub>42</sub> and 108% (OR = 2.08, 95% Cl, 1.27-3.46) for pTau181/Aβ<sub>42</sub>. Our results suggest that higher arterial stiffness is associated with AD CSF biomarker positivity.
Authors
- Álvaro Alonso (ORCID: https://orcid.org/0000-0002-2225-8323)
- Matthew Gold (ORCID: https://orcid.org/0009-0007-1214-9469)
- Erik C. B. Johnson (ORCID: https://orcid.org/0000-0002-0604-2944)
- Hyena Kim
- Felicia C. Goldstein (ORCID: https://orcid.org/0000-0003-2688-3617)
- Ambar Kulshreshtha (ORCID: https://orcid.org/0000-0003-4610-1352)
- James J. Lah (ORCID: https://orcid.org/0000-0002-8810-620X)
- Arshed Ali Quyyumi (ORCID: https://orcid.org/0000-0002-8166-679X)
Institutions
- Emory Healthcare (US)
- Emory University (US)
- Emory Clinic (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1177/13872877251331235
- Citations
- 4
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- National Institute on Aging