Non-enzymatic modification of aminophospholipids induces angiogenesis, inflammation, and insulin signaling dysregulation in human renal glomerular endothelial cells in vitro
Lipid-AGEs induce angiogenesis, inflammation, and insulin signaling disruption in HRGEC, contributing to endothelial dysfunction. These findings underscore the potential role of lipid-AGEs in age-related decline of renal function, as well as the pathogenic potential in DN highlighting their relevance as therapeutic targets for mitigating vascular and metabolic complications in diabetes.
Authors
- Jaime Uribarri (ORCID: https://orcid.org/0000-0001-9826-1134)
- Meritxell Martin‐Garí (ORCID: https://orcid.org/0000-0003-0539-7775)
- Omar Ramírez‐Núñez
- Rebeca Berdún
- John Cijiang He (ORCID: https://orcid.org/0000-0002-1502-2849)
- Manuel Portero-Otı́n (ORCID: https://orcid.org/0000-0002-1823-0299)
- Joan Prat
- Anna Fernàndez‐Bernal
- Pascual Torres (ORCID: https://orcid.org/0000-0001-7903-3478)
- Reyna Rodríguez-Mortera (ORCID: https://orcid.org/0000-0003-4679-1955)
- Reinald Pamplona (ORCID: https://orcid.org/0000-0003-4337-6107)
- José CE. Serrano
Institutions
- Universitat de Lleida (ES)
- Instituto de Investigación Biomédica de Lleida (ES)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.04.030
- Citations
- 2
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 2.64