The Harmful Effect of a Slimming Drug Compared to a Mix of Some Plants Extract on Rats

Background: Xenical drug impact was used for studying losing weight by testing some physiological parameters in male rats compared to (Hatra herbs®) plants extract used for slimming. Methods: ALT,AST,ALP,B.UREA Creatinine, lipids profile, TSH, T4 and T3 were examined. male rats separated into 3 groups: control group, a Xenical group (120 mg\kg b.wt) and a mix plants extract group (200 mg\kg b.wt). Result: Results showed that body weight, cholesterol, triglyceride, VLDLand LDL had a significant drop in plants extract group compared to control, whilst ALTandAST showed a substantial rise in Xenical group compared to control also a significant surge in ALP in both treated groups compared to control . on other hand had, T3 and TSH had a significant reduced in Xenical group, while T3 showed non significant differences in plants extract group compared to control ,in the meantime T4 exhibited increased significance in Xenical group and non significant differences in plants extract group compared to control. B.urea showed a significant escalation in Xenical group compared to plants extract group and control, while creatinine noted no significant differences in all treated groups compared to control group.