Combining network pharmacology and experimental verification to explore the inhibitory effects of Deoxyelephantopin (DET) Against Non-Small Cell Lung Cancer (NSCLC)
This study aims to investigate the inhibitory effect of DET on NSCLC by combining network pharmacology and experimental methods. The results demonstrate that DET effectively inhibited the proliferation of H460 cells and induced apoptosis, with significant involvement of the AGE-RAGE and TNF signaling pathways, suggesting its potential as a therapeutic intervention for NSCLC.
Authors
- Shenjia Wu
- Rong Wang (ORCID: https://orcid.org/0000-0002-2019-8929)
- Ying Guo (ORCID: https://orcid.org/0000-0002-1035-9864)
Institutions
- Fuyang Normal University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s12885-025-14066-3
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fuyang Normal University