Exploring the role of gut microbiota in intervertebral disc degeneration: insights from bidirectional Mendelian randomization analysis
We used a bidirectional Mendelian randomization approach to identify various gut microbiota associated with IVDD. Our findings lay the foundation for further exploration of the pathogenesis and treatment strategies of gut microbiota and IVDD, and provide new possibilities for research on biomarkers of IVDD-related metabolic microbiota.
Authors
- Jiheng Xiao (ORCID: https://orcid.org/0000-0003-1133-4703)
- Tianyi Xia (ORCID: https://orcid.org/0000-0001-9341-7742)
- Xing Xin (ORCID: https://orcid.org/0000-0002-4313-3431)
- Yingze Zhang (ORCID: https://orcid.org/0000-0001-8042-6105)
- Xianglong Zhou (ORCID: https://orcid.org/0000-0002-5867-2964)
- Liming Xiong (ORCID: https://orcid.org/0000-0002-9003-4671)
- Weiqi Zhang (ORCID: https://orcid.org/0009-0009-2536-9529)
Institutions
- Hebei Medical University (CN)
- Union Hospital (HK)
- Third Hospital of Hebei Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- European Spine Journal
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1007/s00586-025-08794-0
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47