The effects of chronic sleep restriction on the hypothalamic-pituitary-adrenal axis and its interaction with abstinence from opioid use
Chronic SR interferes with HPA axis dynamics in sexually dimorphic ways that are expected to differentially affect SR-induced pathophysiology and disease risks. Chronic SR caused the HPA axis abnormalities observed during abstinence, providing a biological linkage between two hypothesized risk factors in vulnerability to drug taking and relapse that demonstrate sexual dimorphisms.
Authors
- Breanna Glaeser
- Christopher M. Olsen (ORCID: https://orcid.org/0000-0003-2700-0310)
- Anikó Szabó (ORCID: https://orcid.org/0000-0002-8129-0614)
- Carol A. Everson (ORCID: https://orcid.org/0000-0002-6903-5581)
- Hershel Raff (ORCID: https://orcid.org/0000-0002-5128-8476)
Institutions
- Medical College of Wisconsin (US)
Publication Details
- Journal
- SLEEP
- Published
- 2025-04-20
- DOI
- https://doi.org/10.1093/sleep/zsaf107
- Citations
- 5
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 5.56