A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice
This mouse strain provides evidence that the exon 6 deletion causes ER stress and inflammation and is an excellent model to understand its contribution to pancreatic cancer and identify preventive strategies.
Authors
- Evangelina López de Maturana (ORCID: https://orcid.org/0000-0001-9425-3911)
- Marina Malumbres (ORCID: https://orcid.org/0000-0003-3823-2512)
- Katelyn E. Connelly (ORCID: https://orcid.org/0000-0002-1693-5519)
- Brice Chanez (ORCID: https://orcid.org/0000-0003-4688-8765)
- Irene Felipe‐Abrio (ORCID: https://orcid.org/0000-0001-7781-1459)
- Sagrario Ortega (ORCID: https://orcid.org/0000-0002-1865-7102)
- Núria Malats (ORCID: https://orcid.org/0000-0003-2538-3784)
- Miguel Lafarga (ORCID: https://orcid.org/0000-0003-3402-1152)
- Laufey T. Ámundadóttir (ORCID: https://orcid.org/0000-0003-1859-8971)
- Raúl Méndez (ORCID: https://orcid.org/0000-0002-1952-6905)
- Isabel Peset (ORCID: https://orcid.org/0009-0004-9374-454X)
- Ana Cayuela (ORCID: https://orcid.org/0000-0001-9515-5213)
- Francisco X. Real (ORCID: https://orcid.org/0000-0001-9501-498X)
- Natalia del Pozo (ORCID: https://orcid.org/0000-0001-5733-6718)
- Pierfrancesco Vargiu
- Jason W. Hoskins (ORCID: https://orcid.org/0000-0001-6944-1996)
- Jaime Martínez de Villarreal (ORCID: https://orcid.org/0000-0002-3003-7766)
- Cristina Bodas (ORCID: https://orcid.org/0000-0002-8108-3359)
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Universidad de Cantabria (ES)
- Universitat Pompeu Fabra (ES)
- Spanish National Cancer Research Centre (ES)
- Instituto de Investigación Biomédica de Lleida (ES)
- National Cancer Institute (US)
- Centro Nacional de Microelectrónica (ES)
- Molecular Oncology (United States) (US)
- Institut Paoli-Calmettes (FR)
- Division of Cancer Epidemiology and Genetics
Publication Details
- Journal
- Gut
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1136/gutjnl-2024-333406
- Citations
- 6
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 12.04
Funders
- Ministerio de Ciencia, Innovación y Universidades