Formulation and characterization of Carbopol based caffeine hydrogel transdermal film

A transdermal patch containing caffeine was developed using Carbopol-940 as the hydrogel matrix. Caffeine transdermal films were made utilizing the solvent casting method with the lipophilic PEG-1500 and hydrophilic carbopol-940. As a plasticizer, propylene glycol (PG) was employed. The drug content, thickness, tensile strength, folding durability, and in vitro drug release—which was investigated using Franz diffusion cells—were all assessed for these films. The purpose of the study was to publish physicochemical data, including in vitro drug release, and the film-forming capabilities of the polymers utilized. PEG-1500, carbopol-940, and PG as a plasticizer were found to have good film-forming qualities. According to the results, the formulation of caffeine made solely with Carbopol-940 and 20% PG was the most flexible and had the best folding endurance of the two polymers employed. Subsequent research on the drug release of PEG 1500 and caffeine has revealed 88.32% and 87.28% release via the rat skin, respectively.