THE EFFECTIVENESS OF IMMUNOMODULATORY THERAPY IN THE TREATMENT OF INFLAMMATORY EAR DISEASES IN CHILDREN AT THE OUTPATIENT LEVEL.

Aim – аssessment of the clinical and immunological efficacy of using the immunocorrective preparation based on topical bacterial lysates «Ismigen» in children aged 3 to 8 years with acute otitis media and a history of recurrent acute respiratory infections. A comparative open study was conducted at the pediatric department of the State Budgetary Healthcare Institution of Samara «SKGP № 15». The patients were divided into two groups. The main group consisted of 31 children who received the standard therapy along with the addition of the immunostimulatory drug «Ismigen». This medication was prescribed according to the following regimen: once daily on an empty stomach in the morning. Treatment included three courses of medication for 10 days each, with a 20-day interval between courses. The comparison group included 24 children who received standard therapy for otitis media and accompanying symptoms without the use of immunocorrective agents. Results. Following comprehensive therapy, after 3 months, the reduction in the overall number of pathogenic and conditionally pathogenic microflora was significantly faster in the group of children receiving «Ismigen». The analysis revealed that after treatment, the level of sIgA in the main group increased on average by 54%. The study confirmed a reduction in the titer of pathogenic microbiota in the nasopharynx and oropharynx in frequently ill children with acute otitis media, as well as a decreased need for additional prescription of other medications, particularly antibiotics, while demonstrating good tolerability and safety of the treatment.