CLOSED AND MANIFESTED CHRONIC HEART FAILURE: POSSIBILITIES FOR EARLY DIAGNOSTICS AND PROGNOSIS WITH APPLICATION OF THE FOLLOW-UP EXPRESS TEST FOR NT-proBNP

Вackground. Chronic heart failure (CHF) is one of the acute problems of modern cardiology due to its prevalence, frequent repeated hospitalizations due to decompensation, high level of disability and mortality. The present article is devoted to the experience of detecting latent and manifest CHF and predicting its course using a domestic semi-quantitative rapid test for NT-proBNP. Purpose of the study. To determine diagnostic and prognostic value of the express-test for NT-proBNP in patients with latent and manifest chronic heart failure. Patient Characterization and Study Methods. 250 patients were included in the open cross-sectional non-randomized cohort study by the method of parallel groups with additional with prospective analysis. The diagnosis of CHF was established in accordance with national and European recommendations. The examination in accordance with the federal standard for this nosology, as well as determination of N-terminal brain natriuretic peptide (NT-proBNP) concentration by quantitative immunochemoluminescent method (analyzer Vitros 3600, Ortho Clinical Diagnostics, USA) and semi-quantitative immunochromatographic method (LLC NPO “BioTest”, Novosibirsk), 6-minute walk test were performed. Methods of statistical analysis. R program was used. Results and conclusion. The study confirmed the previously established diagnostic value of semi-quantitative method on NT-proBNPexpress; revealed that NT-proBNP class 3 level of 450-900 pg/ml correlated closely with hospitalizations due to decompensation of CHF within 6 months.