Effect of shigru (Moringa oleifera Linn.) patra choorna tablet in the management of subclinical hypothyroidism- A single arm open labeled clinical trial

Background: Due to increasing global incidence of Thyroid disorders and their effect on day today life, numerous studies are being conducted to identify potential treatment for Anukta vyadhis. So many drugs have been known for Thyroid controlling properties; but researches regarding its clinical efficacy are less. Objectives: The purpose of this study was to evaluate the effectiveness of Shigru (Moringa oleifera Linn.) Patra churna tablet in the management of Subclinical Hypothyroidism. Materials & Methods: In this single arm open labeled clinical trial , all eligible participants were assigned to receive the intervention without randomization. Patients visiting Specialty OPD of KLE Ayurveda Hospital, Belgavi with signs & symptoms of Subclinical hypothyroidism like weight gain, hair-fall, edema, irregular menstrual cycle and 30 patients of 20 to 60 years age group of either sex without any history of Thyroid related disease, Diabetes Mellitus or Hypertension were included; TSH value above normal range but below 10 IU/L. Shigru patra churna tablet was given 1 gm twice a day before food for period of 42 days. The assessment of changes observed in Thyroid profile as well as in Anthropometrical changes like waist circumference and weight loss and clinical symptoms like Keshapatana (Hairfall), Medovriddhi(gradual weight loss), Shotha (Facial or generalized edema), Aniyamita artava (Menstrual disturbance), Klama (Lethargy or easy fatigue) was carried out. Results: After 42 days of intervention, Thyroid profile, especially TSH and other parameters were significantly decreased when compared with baseline. No adverse drug reaction was reported during and after the intervention with the use of study drug. Conclusion: Shigru patra churna was effective in the management of subclinical hypothyroidism and free from any adverse effect on patients.