Linking a polyketide synthase gene cluster to 6-pentyl-alpha-pyrone, a Trichoderma metabolite with diverse bioactivities
Our findings establish pks1 as an essential gene for 6-PP biosynthesis in T. atroviride, providing novel insights into the production of one of the most significant compounds of this mycoparasite. These findings may pave the way for the development of improved biocontrol agents and the application of 6-PP as potent biopesticide contributing to an eco-friendly and sustainable way of plant disease management.
Authors
- Maria Doppler (ORCID: https://orcid.org/0000-0002-6629-0536)
- Siebe Pierson (ORCID: https://orcid.org/0000-0002-4315-7943)
- Daniel Flatschacher (ORCID: https://orcid.org/0000-0001-8221-9695)
- Rainer Schuhmacher (ORCID: https://orcid.org/0000-0002-7520-4943)
- Veronika Ruzsányi (ORCID: https://orcid.org/0000-0001-9631-364X)
- Mario Gründlinger
- Susanne Zeilinger (ORCID: https://orcid.org/0000-0003-3112-0948)
- Valentina Stock (ORCID: https://orcid.org/0009-0005-6942-4527)
- Alexander Eschlböck
- David Ruso
- Ulrike Schreiner
- Christoph Büschl
Institutions
- Universität Innsbruck (AT)
- BOKU University (AT)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s12934-025-02718-9
- Citations
- 5
- Primary Topic
- Plant-Microbe Interactions and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 8.75