Engineering a PhrC-RapC-SinR quorum sensing molecular switch for dynamic fine-tuning of menaquinone-7 synthesis in Bacillus subtilis
In summary, the PhrC-RapC-SinR QS system has been successfully integrated with biocatalytic functions to achieve dynamic metabolic pathway control in BS168, which has potential applicability to a large number of microorganisms to fine-tune gene expression and enhance the production of metabolites.
Authors
- Mingyu Guo
- Tao Wei (ORCID: https://orcid.org/0000-0003-3816-8127)
- Yongyuan Liu
- Changqing Wu (ORCID: https://orcid.org/0000-0003-4369-9045)
- Xuli Gao (ORCID: https://orcid.org/0000-0001-9814-8342)
- Yani Luo
- Lin Chen (ORCID: https://orcid.org/0000-0003-3876-1916)
- Jing Wu (ORCID: https://orcid.org/0009-0007-0942-5418)
- Yan Liu (ORCID: https://orcid.org/0000-0003-0454-1181)
- Elvis Kwame Adinkra
Institutions
- Wuhu Institute of Technology (CN)
- Anhui Polytechnic University (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s12934-025-02714-z
- Citations
- 7
- Primary Topic
- Vitamin K Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.84
Funders
- National Natural Science Foundation of China