Sarcoidosis Mimicking Malignancy: An Elderly Male With Hypercalcemia and Systemic Symptoms

Sarcoidosis is a multi-system granulomatous disease of unknown etiology that can present with various systemic symptoms and laboratory abnormalities, including hypercalcemia. This case report describes a 74-year-old male who presented with hypercalcemia, weight loss, fatigue, and low-grade fevers, initially raising concern for malignancy. A lymph node biopsy revealed non-caseating granulomas consistent with sarcoidosis. Elevated angiotensin-converting enzyme (ACE) levels further supported the diagnosis. This case highlights the importance of considering sarcoidosis in the differential diagnosis of hypercalcemia and systemic symptoms, especially in elderly patients with complex medical histories.

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Journal
Cureus
Published
2025-04-20
DOI
https://doi.org/10.7759/cureus.82649
Primary Topic
Sarcoidosis and Beryllium Toxicity Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Sarcoidosis Mimicking Malignancy: An Elderly Male With Hypercalcemia and Systemic Symptoms

Thamer Samha, Luaie Idris, Hadiza Ibrahim, Adil Jumani
Cureus
Sarcoidosis and Beryllium Toxicity Research
article

Sarcoidosis Mimicking Malignancy: An Elderly Male With Hypercalcemia and Systemic Symptoms

Thamer Samha, Luaie Idris, Hadiza Ibrahim, Adil Jumani
article en

Abstract

Sarcoidosis is a multi-system granulomatous disease of unknown etiology that can present with various systemic symptoms and laboratory abnormalities, including hypercalcemia. This case report describes a 74-year-old male who presented with hypercalcemia, weight loss, fatigue, and low-grade fevers, initially raising concern for malignancy. A lymph node biopsy revealed non-caseating granulomas consistent with sarcoidosis. Elevated angiotensin-converting enzyme (ACE) levels further supported the diagnosis. This case highlights the importance of considering sarcoidosis in the differential diagnosis of hypercalcemia and systemic symptoms, especially in elderly patients with complex medical histories.

CureusVol. 17(4)
Zayed Military Hospital (AE)
Good health and well-being
Openalex Percentile: Top 90%
Sarcoidosis and Beryllium Toxicity Research
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